The Music Wizard is a Mac/PC based game that works with any MIDI guitar. It comes with its own Washburn guitar and MIDI pickup which acts as the game’s controller.
Unlike the Guitar Hero games, since you are using a real guitar you will actually end up learning how to play the guitar as you play the game. It has a 4-step learning method and will also teach its players how to read music.
This product won’t be available for awhile, Fall 2008. It’ll cost around $180 which is cheaper in the long run than music lessons.