Someone is always trying to invent a better computer mouse. Over the years, I have seen mice made in all sorts of styles for ergonomics and comfort and in different designs for various reasons. All of the mice I have seen have been for the hands though.
A concept mouse called the Toe Mouse has popped up over at Yanko Design. This is certainly not a mouse I would want to share around the office. The idea is that the mouse slips between the big toe and second toe like a flip flop.
The big toe acts as the left click and the second toe is the right click. The only issue I see is that it might be hard for some people to click the right button with the second toe without clicking the left button as well. I guess it depends on your toe dexterity.